BENNETT LAB

Perla, S., Stiegler, A. L., Yi, J.S., Enyenihi, L., Riaz, M., An, E., Qyang, Y., Boggon, T. J. and Bennett, A.M. (2025) SHP2 genetic variants in NSML-associated RASopathies disrupt PZR-IRX transcription factor signaling axis, Proc. Natl. Acad Sci., Issue 35, DOI: 10.1073/pnas.2503631122.

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Skeens, E., Maschietto, F., Ramu, M., Shillingford, S., Lolis, E., Batista, V., Bennett, A.M.* and Lisi, G.* (2025) Dynamic and structural insights into allosteric regulation of dual-specificity phosphatase MKP5, Nat. Comm., Vol. 16, Issue 1, Pages 7011. DOI: 10.1038/s41467-025-62150-w

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Hota, A. and Bennett, A.M. (2025) MAP Kinase Phosphatases in Metabolic Disease, Trends in Endocrinology and Metabolism, S1043-2760(25)00101-8. 10.1016/j.tem.2025.05.002.

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Dorry, S. J., Perla, S., Bennett, A. M. (2024) Mitogen-activated protein kinase phosphatase-5 is required for TGF-β signaling through a JNK-dependent pathway, Mol. Cell. Biol., Nov 28: 1-15. PMID: 39607740 PMCID: PMC11693473

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Fortier, S.M., Walker, N., Penke, L.R., Baas, J., Huang, S.K., Speth, J., Bennett, A.M., Peters-Golden, M. (2024) Dual-specificity phosphatase-1 (DUSP1/MKP1) inhibition of p38α within lung myofibroblasts is essential for spontaneous fibrosis resolution, J. Clin. Invest. Vol. 134 Issue 10, DOI: 10.1172/jci172826.

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Qiu, B., Lawan, A., Xirouchaki, C. E., Yi, J-S, Robert, M., Zhang, L., Brown, W., Fernández-Hernando, C., Yang, X., Tiganis, T. and Bennett, A.M. (2023) Dual-specificity phosphatase MKP1 regulates LKB1-AMPK-caspase 6 mediated hepatocyte death to promote nonalcoholic steatohepatitis, 2023, Nat. Comm., 2023 Vol. 14 Issue 1 Pages 5405. PMCID: PMC10480499​

 

Shillingford, S., Zhang, L., Surovtseva, Y., Dorry, S., Lolis, E. and Bennett, A.M. (2022) A novel site on MKP7/DUSP16 is required for catalysis and MAPK binding, J Biol Chem. 2022 Oct 19:102617. doi: 10.1016/j.jbc.2022.102617.

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Yi, J.S., Perla, S. and Bennett, A.M. (2022) An assessment of the therapeutic landscape for the treatment of heart disease in the RASopathies, Cardiovascular Drugs Ther., DOI: 10.1007/s10557-022-07324-0.

 

Yi, J.S., Perla, S., Mizuno, K., Vinks, A., A. and Bennett, A.M. (2021) Low-dose dasatinib ameliorates hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines, Cardiovascular Drugs Ther., DOI: 10.1007/s10557-021-07169-z.

 

An allosteric site on MKP5 reveals a strategy for small molecule inhibition (2020) Gannam, Z.T.K., Min, K., Shillingford, S.R., Zhang, L., Herrington, J., Abriola, L., Gareiss, P.C., Pantouris, G., Tzouvelekis, A., Kaminski, N., Zhang, X., Yu, J., Jamali, H., Ellman, J.A., Lolis, E., Anderson, K.S., and Bennett, A.M., Science Signaling, 13(646).

 

Yi, J.S., Zhang, Perla, S., Enyenihi and Bennett, A.M. (2020) Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines, J. Clin. Invest. Insight., 5(15):e137753.

 

Bennett, A.M. and Lawan, A. (2020) Improving Obesity and Insulin Resistance by Targeting Skeletal Muscle MKP-1, J. Cell Signal. 1(4): 160-168.

 

Xylourgidis, N., Kisuk, M., Ahangari, F., Yu, G., Herazo-Maya, J., Karampitsakos, J., Aidinis, V., Binzenhöfer, L., Bennett, A.M., Kaminski, N. and Tzouvelekis, A. (2019) Role for MKP-5 in the development of idiopathic pulmonary fibrosis, American Journal of Physiology-Lung Cellular and Molecular Physiology. 2019;317(5):L678-L689.

 

Lawan, A., Min, K., Canfran-Duque, A., Jurczak, M., Camporez, J. P. G., Nie, Y., Gavin, T.P., Shulman, G.I., Fernández-Hernando, C. and Bennett, A.M. (2018) Skeletal muscle-specific deletion of MKP-1 reveals a p38 MAPK/JNK/Akt signaling node that regulates obesity-induced insulin resistance, Diabetes, 67: 624-635.

 

Lawan, A. and Bennett, A.M. (2017) Mitogen-Activated Protein Kinase Regulation in Hepatic Metabolism, Trends in Endocrinology and Metabolism, Vol. 28, No. 12

 

Lee, H., Min, K., Yi, J.S., Shi, H., and Bennett, A.M. (2017) A phosphoproteomic screen identifies a guanine-nucleotide exchange factor for Rab3A as a MAP kinase phosphatase-5-regulated MAP kinase target in IL-6 secretion and myogenesis, J. Biol. Chem., jbc.M116.769208. doi: 10.1074/jbc.M116.769208.

 

Yi, J.S., Huang, Y., Kwaczala, A., Kuo, I., Ehrlich, B.E., Campbell, S., Giordano, F. and Bennett, A.M. (2016) Low-dose dasatinib selectively rescues cardiac function in a Ptpn11 mutant mouse model of Noonan syndrome, J. Clin. Invest. Insight;1(20):e90220.

 

Lawan, A., Zhang, L., Min, K., Gatzke, F., Jurczak, M.J., Al-Mutairi, M., Richter, P., Camporez, G., JP, Couvillon, A., Roth Flach, R. J., Shulman, G. I., and Bennett, A. M. (2015) Hepatic MAP kinase phosphatase-1 Selectively Regulates Glucose Metabolism and Energy Homeostasis, Mol. Cell. Biol., 35: 26-40.